Penn Medicine is one of the world’s premier academic medical centers, uniting the University of Pennsylvania Health System (UPHS) and the Perelman School of Medicine—America’s first medical school, founded in 1765. In Fiscal Year 2023, the Perelman School stood out as a leading recipient of NIH funding, securing $580 million to fuel its pioneering work. Over its storied history, Penn Medicine has spearheaded groundbreaking medical advances, including CAR T cell therapy for cancer and the Nobel-winning mRNA technology crucial to COVID‑19 vaccines. The system comprises a wide network of hospitals and facilities—from the historic Pennsylvania Hospital (chartered in 1751) to modern centers like Lancaster General Health and Penn Medicine at Home—serving communities across Pennsylvania and New Jersey. Today, Penn Medicine is an $11.9 billion enterprise, supported by nearly 49,000 talented faculty and staff, deeply committed to medical education, research excellence, compassionate patient care, and community service.

In 2025, Penn Medicine’s institutions maintained their status among the region’s best, earning top rankings in the Philadelphia area and statewide by U.S. News & World Report—one of the few in Pennsylvania on the nationwide honor roll for specialties such as cancer, geriatrics, and neurology/neurosurgery—despite not submitting data for ranking participation.