

Drex DeFord
Principal
229Project
About Drex
I'm a farm-kid from Indiana. With no money for college, I enlisted in the Air Force as an IT Specialist. While on active-duty and working full-time, I finished my undergrad in Business (Magna Cum Laude), and my first masters degree (Public Administration). The Air Force offered a direct commission as a USAF Officer (hospital administration) -- and I accepted. As a USAF officer, I was the CIO at a small hospital; the Administrator of an Air Transportable Hospital (like an Air Force version of a MASH unit) during Desert Shield/Storm -- shot at and missed; Deputy CIO at the USAF School of Healthcare Sciences; completed a second masters (MS in Health Informatics), CIO at the Air Force's Largest Regional Command (14 hospitals and clinics across the Southern US); CIO at one of the AF's largest Medical Centers; went back to the Middle East to lead an expeditionary hospital supporting multi-national warfighters enforcing Iraqi No-Fly-Zone Operations (Operation Southern Watch); then off to Washington DC as the Chief Technology Officer for Air Force Health System's World-Wide Operations. After 20 years and 21 days of military service I retired from the USAF, and started a civilian career that's included CIO roles at Scripps Health, Seattle Children's, and Steward Healthcare, and CEO of Next Wave Connect. I hung out my shingle as an independent consultant, launching drexio digital health in early 2015. Now, I am joining the This Week Health team as the President of 229, Risk and Security.
Episodes featuring Drex
311 episodes


Newsday: Hackers Outpace Healthcare Resilience and Surviving a Merger with Drex and Bill

2 Minute Drill: What Hackers Can Teach Healthcare About Resilience with Drex DeFord

2 Minute Drill: Building an Agentic AI Hacker with Drex DeFord

Newsday LIVE at HIMSS '26: AI Agents, Workforce Reality, and the CIO Pressure Cooker

2 Minute Drill: How a Cybersecurity Researcher Took Down a Hacker with Drex DeFord

2 Minute Drill: Accidentally Raising Your Own Robot Army with Drex DeFord

Newsday: Rapid Innovation, Safe AI, and the Chief Velocity Officer with This Week Health

The 229 Podcast: The Golden Retriever Problem - AI Agents That Won't Stop Digging with Drex DeFord

Newsday: All About Moltbook, the Social Media for AI Agents with This Week Health

2 Minute Drill: Protecting Revenue from Cyber Attacks - The CFO-CISO Partnership with Drex DeFord
